Calciphylaxis is associated with abnormalities in which lab values?

Calciphylaxis is primarily associated with abnormalities in calcium, phosphorus, and parathyroid hormone (PTH) levels. This condition is a rare but serious disorder characterized by the calcification of small blood vessels, leading to skin ulcerations and necrosis, especially in patients with chronic kidney disease, particularly those on dialysis.

In the context of calciphylaxis, disturbances in mineral metabolism are significant. Hyperphosphatemia (elevated phosphorus levels) and hypercalcemia (elevated calcium levels) often occur as a result of chronic kidney disease, where the kidneys are unable to adequately excrete phosphorus. This dysregulation can lead to secondary hyperparathyroidism, where PTH levels are elevated in response to low calcium levels as the body attempts to maintain calcium homeostasis. Therefore, monitoring calcium, phosphorus, and PTH levels is critical in managing patients at risk for or diagnosed with calciphylaxis.

The other lab values mentioned in the choices do not have a direct association with calciphylaxis. Sodium and potassium levels are more relevant in contexts of hydration status and electrolyte balance, glucose and insulin levels pertain to metabolic conditions such as diabetes, and albumin and bilirubin levels are indicators of liver and nutritional